All of the other loci showed the expected increase in statistical significance (Supplementary Fig. We compared the effects of these loci between the previous 2 and current analysis and found that only one locus did not replicate (rs72711165). We found a total of 23 genome-wide significant loci ( P < 5 × 10 −8) of which 20 loci remain significant after correction for multiple testing ( P < 1.67 × 10 −8) to account for the number of phenotypes examined (Fig. Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals) (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals) and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Here we present meta-analyses bringing together 60 studies from 25 countries (Fig.
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“I found loads of snapdragon, catnip, willow, feverfew and celandine poppy fer ye. Although, to be fair, he had been working out in the practice field of late, building up his strength and skills, he admitted to himself as Rory finally stumbled out into the clearing and greeted him with the question, “How did ye do?”Ĭonran turned from his saddlebag and stepped back to reveal the way it bulged. He was the odd man out in the family-a healer rather than a warrior. Not that Rory would be interested in accompanying them anyway. Which was why he and his other brothers never took him with them when they went on one. He’d be murder on a hunt, Conran thought. He stomped through the woods, snapping branches underfoot like it was his task in life to scare away all wildlife. An Excerpt from The Trouble With Vampires The Trouble With VampiresĬonran heard his brother Rory approaching before he ever spoke. Rules Be KindĮvery interaction on the subreddit must be kind, respectful, and welcoming. 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Resource links will direct you to Wiki pages, which we are maintaining. Please be aware that the sidebar in 'old' Reddit is no longer being updated with information about Book Clubs and AMAs as of October 2018. Evelyn’s hysterical reaction to the fender bender seems crazily out of proportion when she shows up on his doorstep that night, and he has Lucia come up to help him understand why she’s so upset. Enter Evelyn Ortega, a diminutive young woman from Guatemala Richard meets when he skids into her Lexus on the iced-over streets. “Blessed with the stoic character of her people, accustomed as they are to earthquakes, floods, occasional tsunamis, and political cataclysm,” 61 year-old Chilean academic Lucia Maraz is nonetheless a bit freaked out by a snowstorm so severe that it's reported on television “in the solemn tone usually reserved for news about terrorism in far-off countries.” Her landlord and boss, the tightly wound Richard Bowmaster, lives right upstairs with his four cats, but he rebuffs her offer of soup and company. Thrown together by a Brooklyn blizzard, two NYU professors and a Guatemalan nanny find themselves with a body to dispose of. Two members of the Suffolk County Coroner’s Office remove one of six bodies that were found shot in Amityville on Nov. In December 1975, a month after DeFeo was convicted of the murders, the Lutz couple and their three young kids moved into the house, which they had reportedly snatched for $80,000. The notorious killer died behind bars on March 12 at 69. Ronald DeFeo Jr. then 23, gunned down his parents and four siblings there on November 13, 1974. but was changed to 108 to deter tourists - was the site of a brutal slaughter. The three-story colonial - its original address was 112 Ocean Ave. Though their story is now widely thought of as a hoax, the Lutz’s so-called horror house continues to fascinate the public. The couple’s terrifying tale of demonic possession inspired the 1977 book “ The Amityville Horror,” a hit 1979 movie of the same name and several sequels, including a 2005 remake. It’s been more than 45 years since George and Kathy Lutz fled their house in Amityville, Long Island, claiming it was haunted by evil spirits. ‘Amityville Horror’ home sells for $1.46 million Would you buy this skeleton-filled Texas home for $125K? I own a ‘haunted’ pub - watch as this ghost shatters a pint glass Tommy Lee’s hillside Calabasas mansion finally sells at a loss This foreshadows the potentially sinister tone that haunts much of the rest of the book. The setting darkens as Connie's dog discovers a Mandrake root, extremely poisonous and known to be harbingers of death in much folklore. Once there, Connie finds her grandmother's house, completely overgrown with weeds and herbs and oddly without any updates there is no electricity, refrigeration, or phone. Still, Connie keeps her updated as the research takes her back to her grandmother's small New England town, Wonderment, Marblehead, Massachusetts. Connie's mother, a leftover hippie, seems sadly detached from and disinterested in Connie's work. Chilton seems overly hopeful that her topic will benefit his own studies, which he will be presenting at the Colonial Association Conference in September. Connie, a historian of "American Colonial Life" is tasked with discovering new angles and a new primary source for her dissertation topic. Connie Goodwin thinks her main conflict is her prickly Harvard doctoral mentor, Professor Manning Chilton, but she finds worse than that in her family's Puritan ancestry while researching to become a professor and finding love. In the parking lot outside, a teen in a wheelchair calls out her name and – unexpectedly – treats her with kindness, an event more shocking than the insults. A male co-worker makes a vile proposition. (Eva's skewed perspective in the book is treated here as objective reality.) A pleasant-looking middle-aged woman approaches her smiling, but slaps her and utters obscenities. When she takes a menial job at a small travel agency, the co-workers are dull-eyed, coarse and hostile. Haunted and lean post-atrocity, Swinton is compelling but miscast, and she sticks out among her boorish American neighbours like a unicorn that has wandered into the cow yard. Sanguine splashes appear in almost every scene of the film, at times absurdly: When Eva stands frozen in front of stacks of tomato soup, there's an odd moment when it seems Andy Warhol must be behind the school killings. Later, she assumes the martyr role, living in a run-down house near the railway tracks amid angry relatives of her son's victims, who splatter her home with red paint while the soundtrack drones old-time work-gang songs. In an early scene we see Eva revelling in the Tomatina tomato-throwing festival in the Spanish town of Bunol, shot from overhead, her red-splattered body being held aloft while she assumes the Crucifixion pose. She was raised to be strong, but planting the seeds of rebellion in Norta is a tougher job than expected-until she stumbles upon a connection that may prove to be the key to the entire operation: Mare Barrow. The second novella focuses on the life of Farley as she works to lead an uprising, eventually finding a leader in Mare. The first novella tells the story of the young Coriane and Tiberias. Steel Scars: Captain Farley exchanges coded transmissions with the resistance as she travels the land recruiting black market traders, smugglers, and extremists for her first attempt at an attack on the capital. A compilation of two short novellas, 'Cruel Crown' provides a glimpse into the past, as well as a bit more insight into the story's present. Queen Song: Queen Coriane, first wife of King Tiberias, keeps a secret diary-how else can she ensure that no one at the palace will use her thoughts against her? Coriane recounts her heady courtship with the crown prince, the birth of a new prince, Cal, and the potentially deadly challenges that lay ahead for her in royal life. Books by Victoria Aveyard CRUEL CROWN 9781409165330 Orion 9781409165330. Summary: The #1 New York Times bestselling series! Discover the truth of Norta's bloody past in this collection of two novella-length prequels to #1 New York Times bestselling author Victoria Aveyard's Red Queen series. The story revolves around the efforts of Honey and Scott, his superior at Farnborough, to prove that an earlier Reindeer crash was due to metal fatigue and so ground the Reindeer fleet before disaster strikes. In Shute's novel - spoilers ahead - the tailplane of the (fictional) Rutland Reindeer (seen above, from the 1951 film version No Highway In The Sky) is believed by an RAE scientist named Theodore Honey to be susceptible to metal fatigue. Having read the novel now, I don't have any actual evidence for this, but there is an intriguing additional parallel which may have been overlooked (or not, I'm no Shute scholar). (And if he did have reason to think that the Comet would have metal fatigue, why not warn de Havilland instead of writing a novel?) My own suggestion was that instead No Highway might have been loosely inspired by the R101 disaster back in 1930, a formative moment in Shute's life. My response was that it seemed unlikely that Shute had any particular insider knowledge which could have led to such a prediction (made before the prototype had even flown) given that he had already been out of the aircraft manufacturing business for some years. A recent comment by J Campbell raised the question of whether Nevil Shute's 1949 novel No Highway was in fact a prediction of the De Havilland Comet airliner's metal fatigue problems, which led to two crashes ('hull losses', in industry parlance) in 1954. Hurston was recommended by her professor, Franz Boas, for a $1,400 fellowship that Woodson and the American Folklore Society’s Elsie Clews Parson were offering. Woodson and the Association for the Study of Negro Life and History (ASNLH) in 1927. Hurston began working as an investigator for Carter G. 1 While Kossola’s story is not representative of the millions of African people enslaved in the United States, it is still important to know his experience and Hurston’s journey to obtain it. Even though the transatlantic slave trade was abolished in the United States in 1807, thousands of Africans were still brought illegally to the United States to be enslaved until the 1860s. Kossola was thought to be the last of the 110 survivors of the Clotilda, which was one of the last slave ships to travel from the United States to Africa. This book told the story of Cudjo Lewis, who was born as Oluale Kossola. In 2018, another impactful work from Hurston, Barracoon, was published. Zora Neale Hurston was an author and anthropologist, known for her works such as Their Eyes Were Watching God and Mules and Men. |