![]() ![]() All of the other loci showed the expected increase in statistical significance (Supplementary Fig. We compared the effects of these loci between the previous 2 and current analysis and found that only one locus did not replicate (rs72711165). ![]() ![]() ![]() We found a total of 23 genome-wide significant loci ( P < 5 × 10 −8) of which 20 loci remain significant after correction for multiple testing ( P < 1.67 × 10 −8) to account for the number of phenotypes examined (Fig. Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals) (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals) and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. ![]()
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